Title: The neuropharmacology of L-theanine(N-ethyl-L-glutamine): A possible neuroprotective and cognitive enhancing agent
Author(s): Nathan, Pradeep J. (Pradeep.Nathan@med.monash.edu.au); Lu, Kristy; Gray, M.; Oliver, C.
Source: Journal of Herbal Pharmacotherapy 6 (2) : 21-30 2006
Abstract: L-theanine (N-ethyl-L-glutamine) or theanine is a major amino acid uniquely found in green tea. L-theanine has been historically reported as a relaxing agent, prompting scientific research on its pharmacology. Animal neurochemistry studies Suggest that L-theanine increases brain serotonin, dopamine, GABA levels and has micromolar affinities for AMPA, Kainate and NMDA receptors. In addition has been shown to exert neuroprotective effects in animal models possibly through its antagonistic effects on group 1 metabotrophic glutamate receptors. Behavioural studies in animals suggest improvement in learning and memory. Overall, L-theanine displays a neuropharmacology Suggestive of a possible neuroprotective and cognitive enhancing agent and warrants further investigation in animals and humans.
Address: Nathan, Pradeep J. ; Monash Univ, Dept Physiol, Behav Neurosci Lab, Monash Ctr Brain and Behav, POB 13F, Clayton, Vic 3800, Australia
ISSN: 1522-8940
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