González-Maeso et al.2 find that the metabotropic glutamate receptor 2 (mGluR2) and serotonin 5-HT2A receptor (2AR) physiologically bind each other, leading to reciprocal regulation of their functions. Agonists that stimulate mGluR2 are antipsychotic, whereas 2AR agonists, such as hallucinogens, have the opposite effect. It is conceivable that the clinically significant anti-schizophrenic effects of LY2140023, an mGluR2 agonist1, derive from reducing the excessive — and hence hallucinogen-like — activity of 2AR. DOI, 2,5-dimethoxy-4-iodoamphetamine.
From the following article:
Neuroscience: A complex in psychosis
Solomon H. Snyder
Nature 452, 38-39(6 March 2008)
doi:10.1038/452038a
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